Distribution of pathogens causing pulmonary infections in ICU and analysis of drug susceptibility

OBJECTIVE To explore the distribution of pathogenic bacteria causing pulmonary infections in ICU and analyze the result of drug susceptibility testing so as to guide the clinical treatment.METHODS The sputum specimens were collected from 68 patients with pulmonary infections who were treated in the ICU from Jan 2011 to Nov 2012,the VITEK microbiological assay system was used for the strain identification,and K-B was adopted for the drug susceptibility testing,and the result of the drug susceptibility testing was statistically significant.RESULTS Totally 124 strains of pathogenic bacteria were isolated from 68 sputum specimens,including 84(67.8%) strains of gram-negative bacteria,21(16.9%) strains of gram-positive bacteria,and 19(15.3%) strains of fungi.Pseudomonas aeruginosa,Klebsiella pneumoniae,Staphylococcus aureus,Stenotrophomonas aeromonas,and Candida albicans ranked the top five species of pathogens,accounting for 27.4%,16.9%,12.9%,11.3%,and 11.3%,respectively.The drug susceptibility testing indicated that the drug resistance rate of the S.aureus to penicillin G was 100.0%,the P.aeruginosa was sensitive to amikacin and was highly resistant to other antibiotics,the K.pneumoniae was highly resistant to amikacin or ciprofloxacin,and the C.albicans was resistant to itraconazole or fluconazole and was the most sensitive to ketoconazole or amphotericin B with the drug resistance rate of 0%.CONCLUSION The gram-negative bacteria are the main pathogens causing pulmonary infections in the ICU,both the gram-positive bacteria and the gram-negative bacteria have produced high drug resistance to commonly used antibiotics.It is necessary to strengthen the detection of pathogens in early stage so as to guide the reasonable clinical use of antibiotics and improve the therapeutic effect.