Novel S-triazine accommodated 5-benzylidino-4-thiazolidinones: synthesis and in vitro biological evaluations

In order to explore various pharmacological effects associated with S-triazine accommodated 5-benzylidino-4-thiazolidinones, a series of compounds based on 5-benzylidene-2-[4-(4,6-bis-dimethylamino-[1,3,5]triazin-2-ylamino)-phenylimino]-thiazolidin-4-one were synthesized. Variation in the functional group at 5-benzylidine ring of thiazolidinone moiety led to a set of compounds bearing S-triazine accommodated with 4-thiazolidinones. Structures of the synthesized final compounds were confirmed by IR, 1H NMR, 13C NMR spectroscopy, ESI mass spectrometry, and elemental analysis. Synthesized compounds were screened against some bacterial and fungal strains using Kirby-Bauer disk diffusion technique and serial broth dilution technique. Synthesized compounds were screened to find out antitubercular activity against Mycobacterium tuberculosis H37RV by L. J. MIC method and BACTEC MGIT method. Relations between structure and its biological activities have been discussed.