Quantitation of immunoglobulins in patients with schistosomiasis mansoni under chemotherapy.

The humoral immune response of patients with intestinal and hepato-intestinal form of Mansoni's schistosomiasis treated with a single dose of Oxamniquine was evaluated by quantitation of IgG, IgM, IgA and IgE. A constant and significant increase of IgE was observed in the majority of patients after treatment. Augmentation of serum IgE after treatment was variable, but a 3 fold increase was observed. IgG increased slightly after treatment in 6 patients, and IgM increased in 5 patients under the same conditions. However, the difference between the levels of IgG and IgM before and after treatment was not significant. IgA levels were within the normal range, before and after treatment.