The rare case of elevated signet ring cell gastric carcinoma with Helicobacter pylori-naïve mucosa.

Patients with Helicobacter pylori-naive mucosa may develop a pale, depressed signet ring cell gastric carcinoma or elevated gastric phenotype carcinoma. Almost all signet ring cell carcinomas are of the flat or depressed type, and elevated lesions are rare. We experienced a case of elevated signet ring cell carcinoma with Helicobacter pylori-naive mucosa. Although the lesion needed to be differentiated from nonepithelial tumor, we diagnosed early and treated with endoscopic submucosal dissection. We report our case along with the relevant literature review.