Pharmacokinetics of Selamectin in Dogs after Topical Application

Some pharmacokinetic parameters of selamectin were determined in male (n = 5) and female (n = 5) Beagle dogs following a topical application at a dose rate of 6 mg/kg. The plasma concentration versus time data for the drug were analysed using a one-compartment model. The maximum plasma concentrations of 12.72±5.13 ng/ml for males and 22.65±11.95 ng/ml for females occurred around 5 days after administration. The area under the concentration–time curve (AUC) was 192.08±63.85 ng.day/ml for males and 370.97±146.87 ng.day/ml for females. The mean residence time was the same in males and females (12.55 days). This study reveals a sex-influence on the disposition of selamectin in the plasma of dogs, which implies that further information will be needed for correlation with efficacy studies in dogs.