Diagnostic and prognostic value of cardiac troponin I assays in patients admitted with symptoms suggestive of acute coronary syndrome.

Abstract Context.—Increasing numbers of patients are presenting to emergency departments with symptoms suggestive of an acute myocardial infarction. Objective.—To demonstrate the comparative performance of the Ortho Vitros Troponin I and Beckman Access AccuTnI assays used to detect myocardial infarction and to develop risk stratification schemes for all-cause death in patients who presented with myocardial ischemia symptoms that were suggestive of acute coronary syndrome (ACS). Design.—The prospective enrollment of patients with ACS and the measurement of serial plasma samples by 2 commercial cardiac troponin I (cTnI) assays. Setting.—A metropolitan medical center that admitted patients with ACS during a 2-month period. Patients.—The study population consisted of 200 consecutively admitted patients who presented with symptoms that were suggestive of ACS. Results.—Correlation scatterplots showed no significant bias between cTnI assays based on 659 specimens across the dynamic range of each assay. Only mino...