Semi-physiological pharmacokinetic/pharmacodynamic (PKPD) model for trabectedin-induced neutropenia

J Hing,J. Perez Ruixo,Kim Stuyckens,Peter Zannikos,Arturo Soto Matos,L. Lopez Lazaro,M. A. Izquierdo,C. Picó,A. Yver,Andrew T. Chow

Semi-physiological pharmacokinetic/pharmacodynamic (PKPD) model for trabectedin-induced neutropenia

2006

J Hing
J. Perez Ruixo
Kim Stuyckens
Peter Zannikos
Arturo Soto Matos
L. Lopez Lazaro
M. A. Izquierdo
C. Picó
A. Yver
Andrew T. Chow

9575 Background: Neutropenia was the trabectedin (T) dose limiting toxicity in phase I studies. The objective of the present study was to develop a semi-physiological PKPD model that describes the ...

Keywords:

Neutropenia
Pharmacodynamics
Trabectedin
Pharmacology
Medicine
Pharmacokinetics
Pathology
dose limiting toxicity
pharmacokinetic pharmacodynamic

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