Chemistry and X-Ray Crystallographic Structure of N-Protected (5-Oxo-1, 3-oxazolidin-4-yl)acetic Acids: Versatile Intermediates in the Synthesis of Peptidomimetics.
1997
The X-ray crystal structures of
[(2′R,4′S)-3′-benzoyl-4′-
benzyl-5′-oxo-2′-phenyloxazolidin-4′-yl]acetic acid 16
and
[(2′S,4′R)-3′-acetyl-4′-
benzyl-5′-oxo-2′-phenyloxazolidin-4′-yl]acetic acid 19
have been determined and their conformations compared to those of
related oxazolidinones. Compounds of the type 16 and 19 have also been
shown to be useful precursors to succinimide-based peptidomimetics
possessing conformational restriction and latent reactivity.
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