Synthesis and antibacterial activity of 3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

A new series of novel 3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-6-aryl-7H-[1,2,4]triazolo[3,4- b][1,3,4]thiadiazine 10(a-j)in good to excellent yield by the reaction of 4-amino-5-(5-methyl-1-phenyl-1H-1,2,3- triazol-4-yl)-4H-1,2,4-triazol3-ylhydrosulfide with a variety of phenacylbromides.The compounds of all the novel new compounds were established by IR,1H,13C NMR,MS and elemental data. The compounds 10(a-j) were evaluated for their antibacterial activity againist four human pathogenic bacteria viz. Escherichiacoli, Klebseillapneumoniae, Shigelladysentriae and shigellaflexnei. Amongst them, compounds containing (4-methylphenyl) moiety 10b,(4- methoxyphenyl) moiety 10c,(4-chlorophenyl) moiety 10d,(4-dichlorophenyl) moiety 10f, showed significant antibacterial activity, almost equal/more than the activity of the standard drug Sterptomycin and Neomycin.All the compounds displayed significant activity against E.coli. Most of the novel new compounds showed appreciable activity against test bacteria as potential molecules for further development.