Enantioselective Synthesis of Spirooxindole Enols: Regioselective and Asymmetric [3 + 2] Cyclization of 3‐Isothiocyanato Oxindoles with Dibenzylidene Ketones.

A novel cinchona-alkaloid-derived organocatalyst has been developed to catalyze the asymmetric regioselective [3+2] cycloaddition of 3-isothiocyanato oxindoles with dibenzylidene ketones. A series of spirooxindole enols could be obtained in high yields with good-to-excellent diastereo- and enantioselectivities.