The pharmacokinetics of promethazine after intravenous administration in camels.

Abstract The pharmacokinetics of promethazine were determined in seven camels ( Camelus dromedarius ) after an intravenous dose of 0·5 mg kg body weight. –1 The data obtained (median and range) were as follows: the elimination half-life (t 1/2β ) was 5·62 (2·84–6·51) h; the steady state volume of distribution (V dss ) was 8·90 (7·10–12·00) L kg –1 , total body clearance (C T ) was 24·5 (17·22–33·65) ml kg –1 min –1 and renal clearance (Cl r ) was 4·81 (1·97–5·48) ml kg –1 min –1