Original Contribution INVESTIGATIONS ON SOME BIOCHEMICAL AND HAEMATOLOGICAL PARAMETERS AFTER TOBRAMYCIN AND AMIKACIN TREATMENT IN FEMALE GOATS

The aim of the present study was to determine the changes in some biochemical and haematological parameters after 5 days intramuscular treatment with tobramycin (5 mg/kg bw) and amikacin (10 mg/kg bw) in six healthy female goats. The results of these studies indicated that in healthy goats, both antibiotics, in therapeutic doses, caused significant rise in plasma creatinine and urea levels, lymphocyte count and decrease in sodium levels, RBC count and haemoglobin concentration (p<0.05). Amikacin sulphate caused significant rise in alkaline phosphatase activity; tobramycin caused significant increase in lactate dehydrogenase activity. On the whole, the results of these studies demonstrate that tobramycin and amikacin have potential for altering biochemical and haematological values in female goats after using therapeutic doses.