Роль мочевой кислоты в системе антиоксидантной защиты организма

Objection: to study the role of uric acid in the antioxidant defense system of the organism in experiment. Material and techniques. The acute hypoxia was simulated by means of withdrawal of 60-65 % blood circulation volume. The haematological indicators and the blood plasma antioxidant activity were estimated. Results. The control group of the animals revealed growth of the levels of uric acid and lactate, pH depression, blood bicarbonate depression and growth of alkalipenia. The blood plasma of these animals possessed pronounced prooxidant activity, which is indicative of the acceleration of free-radical processes. The control group of the animals detected a strong negative correlation between the uric acid concentration and POA of blood plasma: rs = -0.89 (p hypoxia emaciates the antioxidant defense system of the organism and develops the oxidative stress. The obtained data indicate that uric acid takes part in the antioxidant defense system of the organism.