РЕКОМБИНАНТНЫЙ ПНЕВМОЛИЗИН ВЫЗЫВАЕТ ОБРАЗОВАНИЕ АНТИТЕЛ И ЗАЩИЩАЕТ МЫШЕЙ ОТ ПНЕВМОКОККОВОЙ ИНФЕКЦИИ

The obtained recombinant pneumolysin (rPLY) Streptococcus pneumoniae in atoxic form. The immunogenic and protective activity of rPLY was studied. It was shown that in the sera of mice after double injection of rPLY, the IgG titer increased by up to 32 times as compared with the sera of intact mice. After the third administration of rPLY, the IgG titer increased by up to 15 times compared with the initial IgG level after the second immunization. The protective activity of rPLY revealed in the experience of active protection in intraperitoneal infection of S. pneumoniae mice.