Intramolecular Palladium-Catalyzed Allylic Alkylation: Enantio- and Diastereoselective Synthesis of [2.2.2] Bicycles

Pd-catalyzed asymmetric allylic alkylation provides both enantio- and diastereoselectivity in formation of bicyclo [2.2.2] octan-2,3-diones and quinuclidin-2-ones, the latter potential precursors to quinine alkaloids.