Asymmetric hydrogenation of ketones using Ir(III) complexes of N-alkyl-N’-tosyl-1,2-ethanediamine ligands

Abstract The combination of an enantiomerically pure N′-alkylated derivative of N -4-toluenesulfonyl-1,2-diphenylethane-1,2-diamine (TsDPEN) with iridium trichloride results in the formation of a catalyst with high selectivity for ketone hydrogenation. Products with enantiomeric excesses of up to 84% were formed. The best results were obtained using a ligand with an n -alkyl chain and ortho -substituted acetophenone derivatives and other hindered derivatives.