The association of dilated perivascular spaces (PVS) and microstructural white matter integrity: A Population-Based Study (394)

Objective: To investigate the association of perivascular spaces (PVS) and loss of white matter microstructure presented by diffusion tensor imaging(DTI) parameters. Background: Increased burden of enlarged PVS seen on brain MRI is a marker of cerebral small vessel disease. As PVSs are small fluid filled structures seldom lead to surrounding parenchymal damage, exploring the relationship of PVS and microstructural changes of cerebral white matter, represented by DTI parameters, may lead to further understanding of its clinical effect. Design/Methods: 1,066 participants from an ongoing population-based cohort who underwent brain MRI were included in the present analysis. Burden of PVS were visually scored in white matter and basal ganglia. We investigated DTI-derived indices including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), using tract-based spatial statistics (TBSS) Results: Diffused distribution of decreased FA and increased MD, AD and RD was found in subjects with higher burden of enlarged PVS in white matter as well as in basal ganglia. Mean values of FA for high burden vs low burden group in white matter and basal ganglia were 0.448 vs 0.456(p Conclusions: Our findings suggested a correlation between PVS enlargement and WM damage. However, in theory, the free fluid within PVS may also contribute to the association between PVS and DTI parameters. Disclosure: Dr. Liu has nothing to disclose. Dr. SHU has nothing to disclose. Dr. Chen has nothing to disclose. Dr. Zhai has nothing to disclose. Dr. Han has nothing to disclose. Dr. Zhou has nothing to disclose. Dr. Ni has nothing to disclose. Dr. Yao has nothing to disclose. Dr. Jin has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Cui has nothing to disclose. Dr. Zhu has nothing to disclose.