Dynamic changes and clinical significance of coagulation,fibrinolytic function and platelet parameter before and after chemotherapy in lung cancer patients

Objective To evaluate the dynamic changes and clinical significance of coagulation,fibrinolytic markers and platelet parameters before and after chemotherapy in lung cancer patients.Methods The prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D),protein C(PC),free protein S(FPS),plasminogen activator inhibitor-Ⅰ(PAI-Ⅰ),platelet total(PLT),plateletcrit(PCT),mean platelet volume(MPV) and platelet distribution width(PDW) were measured in sixty lung cancer patients before and after chemotherapy,with twenty healthy people as control.Results Compared with the control group,the mean value of FIB,D-D,PAI-Ⅰ,PLT,PCT and MPV were significantly increased(P0.05 or P0.01) in patients with lung cancer while the mean value of PC and FPS was decreased(P0.05).Compared with the pre-treatment patients,the mean value of PT,TT,APTT,FIB,D-D,PC,FPS,PLT,PCT and MPV was significantly decreased(P0.05 or P0.01) in post-treatment patients.However,the mean value of PAI-Ⅰ was increased(P0.01).There existed no relationship between the plasma level of coagulation,fibrinolytic markers,platelet parameters,sex,histological classification,TNM stages,and metastasis in lung cancer patients before or after chemotherapy(P0.05).Conclusion The state of hypercoagulability,secondary hyperfibrinolysis and low anticoagulation occur among patients with lung cancer.Chemotherapy may enhance blood coagulation functional disorders.