Microcapsule formulations and manufacturing method thereof

【Task】 You can avoid contact with the direct organic solvent layer peptidic physiologically active substance, using a biodegradable polymer, encapsulation efficiency peptidic physiologically active substance to provide a method of manufacturing a high micro-capsule formulation. A In an aqueous solvent containing a heavy metal salt of the peptide physiologically active substance, a basic amino acid was added to obtain an amino acid-containing S / W type suspension process A, In an organic solvent containing a biodegradable polymer, a basic amino acid is added, Step B to obtain the amino acid-containing polymer solution, Wherein the amino acid-containing S / W type suspension is dispersed in an oil phase which is the amino acid-containing polymer solution, obtaining a S / W / O type emulsion C, The S / W / O type emulsion was dispersed in an aqueous phase, obtaining a S / W / O / W emulsion D, and Step E of removing the organic solvent in the S / W / O / W type emulsion including, Method for producing a microcapsule formulation. .BACKGROUND