Determination of the solubility of 6-Chloro-7-azapurine in twelve single solvents and four binary mixed solvent systems at T= (278.15–323.15) K

Abstract The work of this article is to measure the solubility of 6-Chloro-7-azapurine in twelve single solvents (methanol, ethanol, isopropanol, n-propanol, n-butanol, tetrahydrofuran, acetone, ethyl acetate, acetonitrile, n-hexane, n-heptane, toluene) and four binary mixed solvent systems (Tetrahydrofuran + ethyl acetate) (Tetrahydrofuran + isopropanol) (Tetrahydrofuran + acetonitrile) (Tetrahydrofuran + methanol) at different temperatures (283.15–303.15 K) under atmospheric pressure. According to the solubility curve, we can see that solubility depends on temperature and solvent composition. The solubility increases with increasing temperature. It has better solubility in alcohols and THF, while alkanes are less effective as solvents. Several mathematical calculation models, such as modified Apelblat, Buchowski–Ksiazaczak λh, simplified CNIBS/R-K, Jouyban-Acree-van't Hoff, Jouyban-Acree-modified Apelblat, Sun and Ma, and KAT-LSER models were used for analysis Experimental solution. The experimental solubility data and calculation model of 6-Chloro-7-azapurine are of great significance for future synthesis process selection and formulation research.