SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation

Fei Liu,Christopher D. Cox,Reshmi Chowdhury,Laura Dovek,Huytram Nguyen,Tie Li,Sichen Li,Byram Ozer,Arthur P. Chou,Nhung Nguyen,Bowen Wei,Joseph P. Antonios,Horacio Soto,Harley I. Kornblum,Linda M. Liau,Robert M. Prins,P. Leia Nghiemphu,William H. Yong,Timothy F. Cloughesy,Albert Lai

SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation

2019

Purpose Both IDH1-mutated and wild-type gliomas abundantly display aberrant CpG island hypermethylation. However, the potential role of hypermethylation in promoting gliomas, especially the most aggressive form, glioblastoma (GBM), remains poorly understood.

Keywords:

Glioblastoma
Cancer research
Wild type
DNA methylation
C-Met
CpG island hypermethylation
Medicine
IDH1
cpg island methylation

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