[Effect analysis on non-and-low response infants after revaccinated hepatitis B vaccine].

Objective To evaluate the booster immunization effect to non-and-low response children after 3 doses HepB immunization.MethodsNon-and-low response infants born in 2004～2005 administered 3 doses of HepB at 0,1,6 months in Guangzhou,Beijing and Zhejiang were divided into 4 groups randomly,and boosted 3 dose of 4 different types of HepB at 0,1,6 months.ResultsThe GMC of non-and-low response children in group A(before booster),group B(after 1 dose booster) and group C(after 3 dose booster) were 18.66mIUml,88.82mIU/ml,178.24mIU/ml respectively;the proportion of non-responders in three groups were 20.4%,9.1%,1.9% respectively.In 103 non-and-low response children,proportion of titers of more than 100mIU/ml of group B and group C were 61.2% and 84.5%,and there was statistical significant difference(c2=14.13,P0.01).The GMC after 3 doses revaccination with four kinds of HepB,included 5g HepB-Y,10g HepB-Y,10g HepB-CHO,10g HepB-HY were 168.8mIU/ml,174.7mIU/ml,184.9mIU/ml,182.9mIU/ml respectively.Proportion of titers of more than 100mIU/ml for four kinds HepB were 79.0%、85.7%、88.2% and 84.6% respectively,and there was no significant difference(c2=0.75,P0.05).ConclusionThere were no different of seroconversion rate between study population received 1 dose and 3 dose booster(P0.05),but high titer was observed after 3 dose booster.The four kinds of HepB,including 5g HepB-Y,10g HepB-Y,10g HepB-CHO,10g HepB-HY had the same immunization effect after 3 doses revaccination at 0,1,6 months to non-and-low response children.