Invasive Rhino-Orbital-Cerebral Aspergillosis of Non-immunocompromised Host

Fungus may spread into upper respiratory tracts of humans and accumulated in paranasal sinuses, causes fungal sinusitis. Aspergillus is the most found pathogen. Invasive aspergillosis often happens in immunocompromised patents. Orbital or deep cranial symptoms including headache, visual loss, diplopia, cranial nerve paralysis or consciousness disturbance may develop, cause rhino-orbital-cerebral aspergillosis. After physical and endoscopic examination, image studies like CT and MRI are required for preoperative surveillance. Intravenous liposomal Amphotericin-B combined with adequate surgical debridement is regarded as the mostly effective therapeutic strategy for infection control. We reviewed a medical history of the 66 year-old gentleman who had no systemic disease before and diagnosed with rhino-orbital-cerebral aspergillosis. After the treatment, he recovered well and no evidence of recurrence was noted after follow-up for six months.