Evidence that selective collateral elimination during postnatal development results in a restriction in the distribution of locus coeruleus neurons which project to the spinal cord in rats

Experiments utilizing retrogradely transported fluorescent tracers in rats reveal that coeruleospinal cells are present throughout the locus coeruleus just after birth, but are confined to its ventral portion by the end of the fourth postnatal week. This change in distribution is not brought about by cell death, since neurons retrogradely labeled through their spinal axon following an injection of tracer shortly after birth are still present in the dorsal locus coeruleus even if the animal is not killed until the end of the fourth postnatal week. Thus the dorsal coeruleospinal neurons in newborn rats do not die but rather lose their spinal collateral.