Expression and clinical significance of GST-π,ERCC1,MRP and LRP in human epithelial ovarian carcinoma

【Objective】 To investigate the expression and clinical significance of the glutathione S-tranferases-π(GST-π),excision repair cross-complement gene 1(ERCC1) multidrug resistance-related protein(MRP) and lung resistance-related protein(LRP) in human ovarian carcinoma and evaluate it's roles in chemoresistance of ovarian carcinoma.【Methods】 The expression of GST-π,ERCC1,MRP and LRP in 67cases of ovarian cancer,20 cases of ovarian benign tumors and 16 cases of normal controls was determined by using immunohistochemical method and the results were studied in correlation with some clinical and pathological data.【Results】 The positive expression rate of GST-π,MRP and LRP in ovarian carcinoma was significantly higher than in benign tumors and normal tissues(P 0.05);A significant relationship was shown the expression of GST-π and pathologic grade as well as clinical stage respectively(P 0.05).【Conclusion】 Co-detection of GST-π,ERCC1,MRP and LRP expression can be used to select reasoned chemotherapy regimens,predict the chemotherapeutic response,and evaluate the prognosis of ovarian carcinoma patients.