Pancreatic adenocarcinoma in young adults (≤45 years old): Characteristics and clinical outcomes from a Canadian center.

260Background: Clinical data concerning pancreatic adenocarcinoma (PAC) in young adults is restricted. Limited evidence might suggest a worse prognosis in terms of overall survival (OS) and progression-free survival (PFS), when compared to an older population. Methods: The studied population included adults ≤45 diagnosed with a PAC (stages I to IV) between January 2006 and December 2016 at University of Montreal Health Center (CHUM), a tertiary care referral center in Canada. Clinical data was retrospectively extracted from chart review. The Kaplan Meier estimator was used for survival analyses. Results: 36 patients were identified in the study (median age 41.6, 56% males). Most patients (61%) had localized disease at diagnosis, with 22% presenting with metastases. The head of the pancreas was the primary site involved in 75% of cases. Most patients (63%) had a positive smoking history, with a median number of pack-years of 15. A personal history of cancer was present in 20% (n = 7) and 14% had a positive...