Systemic and Local Immunological Activity of Lymph Node Cells from Mice Treated with Antilymphocyte Serum

SummaryAn immunosuppressive antilymphocyte serum prolonged the survival of skin allografts and suppressed the systemic graft-versus-host reactivity of lymph node cells from treated mice. Those same lymph node cells, however, were highly reactive when tested in the skin of the X-irradiated hamster, and that reactivity was dependent, at least in part, upon the presence of viable, histoin-compatible cell populations. We conclude that cells from the ALS-treated mice react well in that local assay while showing suppressed reactivity in the systemic assays of immunocompetence.