Observation of the efficacy of neoadjuvant chemotherapy combined with conserving-breast surgery in the treatment of patients with stage II, III breast cancer

Objective To observe the efficacy and safety of neoadjuvant chemotherapy combined with conserving-breast surgery in treatment of patients with stage Ⅱ, Ⅲ breast cancer. Methods 85 patients with stage Ⅱ, Ⅲ breast cancer were selected, 42 patients in breast-conserving group and 43 patients in modified radical group.Neoadjuvant chemotherapy was used in breast-conserving, while was not used in modified radical group.Efficacy and follow-up results were observed in the two groups. Results After treatment, the CR and PR in the breast-conserving group was 30 cases and the effective rate was 71.4%, which of the modified radical group was 55.8% with 21 patients of CR and PR.After the comparative analysis, the difference was statistically significant(t=4.518, P=0.034). After followed for 12-36 months, the patients in the breast conserving group were all alive and one case of local recurrence.According to breast shape evaluation criteria, 34 patients were excellent, accounting for 80.9%; good for the five cases, accounting for 11.9%; bad of two cases, accounting for 4.8% and the excellent rate was 92.9%.According to the patients' own judgment on the breast shape, 37 cases were very satisfied, accounting for 88.1%; basic satisfaction for three cases, accounting for 7.1%; dissatisfied 2 cases, accounting for 4.8% and the satisfaction rate was 95.2%. Conclusion Patients with breast cancer of Ⅱ, Ⅲ period before breast-conserving surgery taking chemotherapy can reduce the clinical stage while the postoperative efficacy and breast appearance are good with important clinical value. Key words: Breast neoplasms; Antineoplastic combined chemotherapy protocols; Breast-conserving surgery