Expression of KGF and E-cadherin in pancreatic adenocarcinoma and their clinical significance

Objective To study the expression of KGF and E-cadherin in pancreatic adenocarcinoma and their clinical significance.Methods The expression of KGF and E-cadherin in 45specimens of paraffin-embeded pancreatic adenocarcinoma and 22 normal pancreas amund tumors was detected by using immunohistochemistry staining(sP)and compared with clinicopathological data.Results The increased expression of KGF in pancreatic adenocarcinoma was significantly higher than that in normal pancreas,the positive rate of KGF was 77.8%(35/45),and there was a relationship between hish KGF expression and the differentiation of carcinoma and the clinical stages(P＜0.05,0.05,respectively).The decreased expression of E-cadherin in pancreatic adenocarcinoma was lower than that in normal pancreas.The higher rate of expression was 35.6%(16/45),and a significant relationship was observed between low Ecadherin expression and the differentiation of carcinoma.the metastasis of lymph nodes and the clinical stages (P＜0.05,0.05,0.01,respectively).The expression between KGF and E-cadherin had a significant relation in pancreatic adenoeareinoma (P＜0.01).Conclusion The level of KGF and E-cadherin may be a sensitive predictor of proliferation,differentiation,invasion and metastasis of pancreatic adenocarcinoma. Key words: Pancreatic neoplasms; Keratinocyte growth tactor; E-cadherin