Anti-Hyperglycemic Activity of Alcoholic Extract of Swertia Tetragona Edgew

Summary The alcoholic extract of Swertia tetragona Edgew was tested for antihyperglycemic activity on normal fasted, glucose loaded and alloxan induced diabetic rats. Blood glucose levels were evaluated at 0,1 and 3 hours in normal fasted rats; at 0, 30 and 90 minutes in glucose loaded rats; at 0, 1 and 3 hours in acute, and at days 1, 3, 7 and 10 in sub-acute studies of alloxan induced diabetic rats after extract administration of 250 mg/kg. In both acute and sub acute-studies the ethanolic extract showed statistically significant anti-hyperglycemic and an enhanced glucose tolerance activity while it had no effect on normal fasted rats.