The Relationship Between Cognitive Dysfunction Through THINC-Integrated Tool (THINC-it) and Psychosocial Function in Chinese Patients With Major Depressive Disorder

Background: Herein, we validate the psychometric properties of the Chinese version of the THINC-integrated tool (THINC-it) as a screening tool for cognitive deficits in patients with major depressive disorder. The primary aim of this study to determine whether cognitive deficits as detected by the THINC-it tool in adults with major depressive disorder (MDD) are associated with workplace productivity and/or psychosocial function. Methods: Subjects aged 18-65 (n=91) with MDD were evaluated and compared to age- and sex- matched healthy controls (n=95). Completed the THINC-it tool. The THINC-it tool, as well as the paper version of the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D), Sheehan Disability Scale (SDS), The Work Productivity and Activity Impairment questionnaire- Specific Health Problem (WPAI-SHP). Results: There were significant differences in THINC-it scores (p0.05). Conclusion: The Chinese version of THINC-it can be used to assess the overall cognitive function of patients with MDD. The subjective cognitive function measured by THINC-it is significantly correlation with the impairment of psychosocial function. Keywords: THINC-it, MDD, Cognitive function, psychosocial function, work productivity