Mapping Quantitatively Regional Drug Absorption in Canines with IntelliCap System

Quantitative regional absorption of a drug under development was studied by using the novel IntelliCap system. IntelliCap is an orally swallowable programmable drug delivery capsule and capable of real-time monitoring of physiological conditions (pH, temperature), consequently allowing localization of the capsule over time by the typicaland consistent physiological pH profiles in dog and man. The plasmaconcentration–time profile could then be correlated to drug absorption (AUC) in different gut regions. Such individual correlations of gut location and plasma drug concentration allow more precise PK datainterpretation. In addition only a single dose in one pass is necessary to map quantitatively site of absorption compared to other systems (e.g. IntelliSite, Enterion) that need one administration for one location in the gut.