Design and synthesis of a series of novel pyrazolopyridines as HIF 1-α prolyl hydroxylase inhibitors
2006
Abstract Recently resolved X-ray crystal structure of HIF-1α prolyl hydroxylase was used to design and develop a novel series of pyrazolopyridines as potent HIF-1α prolyl hydroxylase inhibitors. The activity of these compounds was determined in a human EGLN-1 assay. Structure-based design aided in optimizing the potency of the initial lead ( 2 , IC 50 of 11 μM) to a potent ( 11l , 190 nM) EGLN-1 inhibitor. Several of these analogs were potent VEGF inducers in a cell-based assay. These pyrazolopyridines were also effective in stabilizing HIF-1α.
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