And in response to star polymers and composites based micelles pH β- cyclodextrin

The present invention belongs to the technical field of biomedical polymer polymer material, and discloses a method for preparing a star polymer based amphiphilic pH β- cyclodextrin response, and based thereon micellar systems and composites and Applications . The polymer having the structure shown in the following formula (a): wherein, x = 3 ~ 20, y = 2 ~ 30, z = 5 ~ 35, n = 2 ~ 10. The polymer can be reduced in situ to give a small particle diameter, good stability gold nanoparticles. The present invention further provides a system based on the above polymer micelle, which enhances the ability of entrapping water-insoluble drug substance may be more efficiently load a hydrophobic drug, the gold particles, to achieve tumor imaging and diagnosis of cancer chemotherapy combination therapy to improve the efficiency of cancer. And the ratio of each polymer block is easily regulated, poorly soluble drug loaded micellar system applicable to the preparation of water to meet the requirements of different drug release.