Nuclear Ca2+ regulates cardiomyocyte function
2008
In the heart, cytosolic Ca 2+ signals are well-characterized events that participate in the activation of cell contraction. In contrast, nuclear Ca 2+ contribution to cardiomyocyte function remains elusive. Here, we examined functional consequences of buffering nuclear Ca 2+ in neonatal cardiomyocytes. We report that cardiomyocytes contain a nucleoplasmic reticu- lum, which expresses both ryanodine receptor (RyR) and inositol 1,4,5-trisphosphate receptor
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