Controller for improved thermal and pressure control for the chromatography

Exemplary embodiments of the present invention include systems, devices and methods that are directed to control the pressure in a pressurized flow system, such as a CO Exemplary embodiments of the present invention comprise one or more devices, systems or methods to implement more pressure regulators to regulate the pressure or control. In addition to the provided pressure regulation or control devices of the invention, systems and methods also dampen damaging thermal effects, including pressure drops by a mobile phase comprising CO