Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Sushrut Kamerkar,Valerie S. LeBleu,Hikaru Sugimoto,Sujuan Yang,Carolina F. Ruivo,Sonia A. Melo,Jiun-Kae Jack Lee,Raghu Kalluri

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

2017

Sushrut Kamerkar
Valerie S. LeBleu
Hikaru Sugimoto
Sujuan Yang
Carolina F. Ruivo
Sonia A. Melo
Jiun-Kae Jack Lee
Raghu Kalluri

Exosomes improve the delivery of siRNA to mutant KRAS in the pancreatic tumours and bypass immune clearance better than artificial liposomes, probably owing to enhanced macropinocytocis and presence of CD47 on exosomes, respectively.

Keywords:

Immune clearance
KRAS
Microvesicles
Liposome
Pancreatic cancer
Gastrointestinal cancer
Mutant
Immunology
CD47
Medicine
Small hairpin RNA
Cancer research
Cancer
Biology
GTPase KRas
Small interfering RNA

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