Frequency of CDH1 germline variants and contribution of dietary habits in early age onset gastric cancer patients in Brazil

Rodrigo Santa Cruz Guindalini,Marina Candido Visontai Cormedi,Simone Maistro,Fátima Solange Pasini,Priscila Abduch Branas,Liliane dos Santos,Gláucia Fernanda de Lima Pereira,Geertruida H. de Bock,Daniela Marques Saccaro,Maria Lucia Hirata Katayama,Sheila F. Faraj,Adriana V. Safatle-Ribeiro,Ulysses Ribeiro-Junior,Maria Del Pilar Estevez Diz,Ana Carolina Ribeiro Chaves de Gouvêa,Roger Chammas,Maria Aparecida Azevedo Koike Folgueira

Frequency of CDH1 germline variants and contribution of dietary habits in early age onset gastric cancer patients in Brazil

2019

Rodrigo Santa Cruz Guindalini
Marina Candido Visontai Cormedi
Simone Maistro
Fátima Solange Pasini
Priscila Abduch Branas
Liliane dos Santos
Gláucia Fernanda de Lima Pereira
Geertruida H. de Bock
Daniela Marques Saccaro
Maria Lucia Hirata Katayama
Sheila F. Faraj
Adriana V. Safatle-Ribeiro
Ulysses Ribeiro-Junior
Maria Del Pilar Estevez Diz
Ana Carolina Ribeiro Chaves de Gouvêa
Roger Chammas
Maria Aparecida Azevedo Koike Folgueira

Introduction The contribution of CDH1 germline variants to gastric cancer burden among young adults is unknown in Brazil. We aimed to evaluate the frequency of CDH1 germline variants and the diet/lifestyle habits in early age onset gastric cancer (EOGC, ≤ 55 years old) patients.

Keywords:

Pathology
CDH1
Hereditary diffuse gastric cancer
Germline
Oncology
Medicine
Cadherin
Young adult
Cancer
Internal medicine
Surgical oncology
Exon
Missense mutation
Multiplex ligation-dependent probe amplification

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