Flurbiprofen ester cyclodextrin inclusion Acetaminophen and its preparation method

The present invention relates to acetaminophen flurbiprofen ester cyclodextrin inclusion compound and its preparation method, this main component of inflammatory and analgesic prodrugs of flurbiprofen for the new compounds of acetaminophen ester by using cyclodextrin inclusion process, the flurbiprofen ester of acetaminophen was dissolved in an organic solvent, an aqueous solution of cyclodextrin or derivatives thereof is added, stirred, water-soluble clathrate formed after drying. Inclusion complex may be further reacted with a suitable excipient blend oral tablets, or capsules. The present invention enables a significant increase in drug solubility and dissolution rate after treatment drug solubility in water is increased by 10 to 100 times greater than the drug, the cumulative dissolution percentage of 45 minutes is also greatly improved in the dissolution medium, and therefore it improves the hydrophobic drug flurbiprofen oral absorption rate of paracetamol ester.