The Natural History of Functional Gastrointestinal Disorders Over 20 Years: A Population Based Study

G A A b st ra ct s The 16519T SNP, but not 3010A, was associated with IBS, and was significantly increased in those with maternal inheritance (Table). IBS patients with PMI were significantly more likely to have the 16519T SNP than controls (66.7% vs 26.3%; OR=5.6 95%CI=1.6-19.2). Conclusions: A significant minority (1/6) of IBS patients have pedigrees that are highly suggestive of maternal inheritance. The mtDNA polymorphism 16519T, which has been previously implicated in other functional disorders, is also associated with IBS, especially in the sub-group displaying maternal inheritance. These findings suggest that mtDNA-related mitochondrial dysfunction constitutes a sub-group within the entity known as IBS. This may have consequences for treatment of these patients. Mitochondrial-targeted treatments like supplementation with co-enzyme Q10 seem to reduce symptoms in patients with other functional disorders such as migraines and cycl ic vomiting (PMID 15728298; PMID20109321) and should be tested in IBS patients withmaternal inheritance. [This study is funded by a grant from the International Foundation of Functional Gastrointestinal Disorders]