Insights into the Treatment of Severe Acute Pancreatitis

Acute pancreatitis is a common gastrointestinal emergency,which comprises mild acute pancreatitis (MAP) and severe acute pancreatitis (SAP).About 80% of cases presents as a mild,self-limiting disease with low morbidity and mortality,however,patients who suffer from SAP will experience serious local and/or systemic complications associated with high mortality.Infection of pancreatic or peripancreatic tissue with necrosis is the most serious complication with a mortality rate as high as 30%.Antibiotics,enteral nutrition and probiotics have been used to prevent the pancreatic infection;however,only enteral nutrition has been proved to be effective.There are still some controversy on the use of antibiotics and probiotics in SAP.