A Pd(II)-Catalyzed Asymmetric Approach Toward Chiral [3.3.1]-Bicyclic Ketals Using 2-Hydroxyphenylboronic Acid as a Pro-Bis(nucleophile).

The first enantioselective synthesis of title compounds (III), (V) and (VII) by a Pd-catalyzed cascade reaction employing a 2-hydroxyphenyl Pd-complex as a bis(nucleophile) generated in situ via transmetallation of boronic acid (II).