Analogues of antimicrobial peptide synthesized and produced from gaegurin 5

The present invention is related to antibiotic peptides designed by systemic peptide engineering using Gaegurin 5 isolated from Korean frog (Rana rugosa), which have smaller structure compared with previously known Gaegurin peptides and shows potent antibiotic activity. Specifically, the antibiotic peptide of the present invention synthesized from the shortest length of Gaegurin named Gaegurin 5 among Gaegurins 1 to 6, show potent antibacterial activity against gram positive and negative strains, good safety with very low hemolytic activity and favorable advantages such as drug absorption and drug transport due to their advantageous structural property, which can be useful as a potent anti-bacterial or anti-fungal agent.