Effects of YBSX Syrup on hematopoietic and immunologic functions in mice treated by chemotherapy

Object To explore the effects of Yibaishengxue (YBSX) Syrup on hematopoietic and immunologic functions of mice pretreated by cyclophosphamide (CTX) and the most proper regime of the administration of YBSX Syrup. Methods YBSX Syrup was ig administered to the prevention group, the treatment group, and the group which combined the prevention and treatment together. The number of blood leucocyte, platelet and bone marrow cell were counted by conventional methods; spleen index was measured by weighing method. Phagocytic rate and index were evaluated by phagocytic effect of peritoneal macrophage (MΦ) on chick erythrocyte, and the content of serum tumor necrosis factor alpha (TNF-α) was assayed by ELISA. Results YBSX Syrup enhanced the count of leucocytes, platelets, and bone marrow cells, improved the level of spleen index and macrophage phagocytic index, and increased the content of TNF-α in serum dose-dependent. Conclusion YBSX Syrup is able to ameliorate the disorders of hematopoietic and immunologic functions induced by CTX, and show the combination of prevention and treatment regime is the best one.