EpCAM-specific chimeric antigen receptor and encoding gene and application thereof

The invention discloses an EpCAM (Epithelial cell adhesion molecule)-specific chimeric antigen receptor. The EpCAM-specific chimeric antigen receptor is obtained by serially connecting a single-chain antibody of a human anti-EpCAM, CH2CH3 of a human antibody IgG1, a transmembrane region and an intracellular signal structure of CD28, an intracellular signal structure of CD137 and an intracellular signal structure of CD3[zeta]. The invention further discloses an amino acid sequence and a nucleic acid sequence of the chimeric antigen receptor. The invention further discloses application of the chimeric antigen receptor to preparation of medicines for treating EpCAM-related tumors, namely modification of T lymphocytes, and the modified lymphocytes can be applied to treatment of the EpCAM-related tumors.