Gender-Specific Outcomes In Patients With Heart Failure And Sepsis Who Received Aggressive Intravenous Fluid Resuscitation

Background Limited data exist about the impact of gender-specific outcomes in patients with heart failure (HF) who develop concomitant sepsis. Methods This is a retrospective cohort study of patients with HF who developed sepsis. Clinical outcomes, including in-hospital mortality, development of cardiogenic shock (CS), volume overload requiring urgent intravenous diuretics (IVD), acute kidney injury (AKI), length of stay (LOS), and 30-day HF-related readmission were evaluated amongst men vs. women. Results This cohort of 618 patients includes 272 (44%) women with a mean age of 75±14 years. Coronary artery disease (p Conclusion Women with HF who developed sepsis receive a more aggressive implementation of the surviving sepsis campaign than men, leading to more volume overload events in women with HFpEF and more cardiogenic shock in women with HFrEF. A cautiously tailored approach is desperately needed for patients with HF who develop sepsis.