Searching for intraocular antibody production against Parvovirus B19, Mumps virus and Measles virus in patients with intermediate and posterior uveitis

Uveitis is a destructive ocular inflammation and is caused by either infectious agents or non-infectious immune reactions. The aetiology is still unknown in about 50% of the patients. The distinction between an infectious and non-infectious aetiology is crucial for treatment and prognosis. The main infectious agents in the West include Toxoplasma gondii , Herpes simplex virus (HSV), Varicella zoster virus (VZV), Cytomegalovirus (CMV) and Rubella virus, pathogens which are also the most frequent causes of congenital and childhood infections. Several case reports have mentioned uveitis following Parvovirus, Mumps or Measles infection.1–3 Despite the MMR-vaccination programme, Mumps and Measles outbreaks continue to occur.4 We hypothesised that other common viral childhood infections might also be able to incite uveitis and selected Parvovirus B19, Mumps virus and Measles virus as the most likely …