Regulation of gap-junctional intercellular comnunication in transformation-sensitive and transformation-resistant BALB/c 3T3 cell variants

BALB/c 3T3 A31-1-13 cells are highly susceptible to chemical-induced cell transformation and their gap-junctional intercellular communication (GJIC) is decreased when these cells become confluent. On the other hand, A31-1-1 cells do not show such a change in GJIC and are more resistant to chemical induction of transformation. In order to see which phenotypes are dominant, cells of these two types were hybridized and the hybrids were analyzed for their phenotypes for GJIC and induction of cell transformation