Endocrine Profile Of Patients With Uterine Cervical Carcinoma

Most human cervical neoplasms are squamous cell carcinomas, which are believed to be hormone dependent. We investigated the role of peptide and steroid hormones in 54 pre-menopausal and 15 post-menopausal women with uterine cervical carcinoma. Circulating FSH, LH, prolactin (PRL), estradiol (E2), progesterone (Pg) and testosterone (T) were estimated. The control group comprised 15 pre-menopausal and 15 post-menopausal healthy, age matched women. In the premeno pausal group, women with cervical cancer had higher levels of FSH (p<0.001), LH (p<0.05) with lower levels of E2 (p< 0.001) and T (p<0.02) than controls. When grouped accorded to disease stage, early stage patients had higher levels of LH (p<0.01) and T (p<0.01) than controls. In addition, there was a trend to higher levels of E2 and Pg. These findings suggest that hormonal imbalance may play a leading role in the pathogenesis of uterine cervical carcinoma; it may precede initiate or accelerate the development of these tumours.