How Coupled are Mass Spectrometry and Capillary Electrophoresis

The understanding of how science works can contribute to making scientific development more effective. In this paper, we report an analysis of the organization and interconnection between two important issues in chemistry, namely mass spectrometry (MS) and capillary electrophoresis (CE). For that purpose, we employed science of science techniques based on complex networks. More specifically, we considered a citation network in which the nodes and connections represent papers and citations, respectively. Interesting results were found, including a good separation between some clusters of articles devoted to instrumentation techniques and applications. However, the papers that describe CE-MS did not lead to a well-defined cluster. In order to better understand the organization of the citation network, we considered a multi-scale analysis, in which we used the information regarding sub-clusters. Firstly, we analyzed the sub-cluster of the first article devoted to the coupling between CE and MS, which was found to be a good representation of its sub-cluster. The second analysis was about the sub-cluster of a seminal paper known to be the first that dealt with proteins by using CE-MS. By considering the proposed methodologies, our paper paves the way for researchers working with both techniques, since it elucidates the knowledge organization and can therefore lead to better literature reviews.